Needed to make some of the changes in this github comment: [https://github.com/ValveSoftware/Proton/issues/308?_pjax=%23js-repo-pjax-container#issuecomment-439692009.]============================================= 1) Had an issue with the camera stopping rotation caused by multi-monitor setup. I had to run winecfg and set up to run Fallout 4 in a virtual desktop and capture the mouse. This works perfectly on the left most monitor. To play on my right monitor I currently need to disable the left monitor as a workaround.================================== 2) Needed to add the pulse_latency startup option to fix audio getting stuck in a loop e.g. constant minigun firing.=============================================== 3) Added the no_esync startup option to fix loading screens, but this isn't 100% fixed which is the only thing preventing a gold rating.================================== 4) I had already added bBackgroundMouse=1 to Fallout4Custom.ini, haven't tested without.

Otherwise good performance, no stutter, no graphical bugs, no physics issues. I haven't tested mods yet.