I was unable to start this game, eventually it startet when I removed gamemoderun from the launch options.
PROTON_NO_ESYNC=1 PROTON_NO_FSYNC=1 %command%

Some dips to ~30fps when looking in some directions.
Game runs fine "out-of-the-box" at 30fps, but turn off volumetric fog and it'll play at 55fps on High. Limit to 50-55hz, anything above that the game goes down to ~40fps. Only problem is when looking in some directions or inspecting a body, the game will go down to 33fps. Not a big deal.
PROTON_ENABLE_NVAPI=1 VKD3D_CONFIG=dxr11 %command%
PROTON_NO_ESYNC=1 gamemoderun mangohud %command%
Crash after extended gameplay
Hard crash because of smoke effects on hanging corpses, both during High Risk section and the one in the hallway
The Mortuary Assistant Ver 1.0.52, Resolution 3840X2160, gamemode on with gpu overclock.
Capped FPS to 60 to reduce effect of FPS drop. Average FPS for me 95-35. Changed over to Proton 6.3-8 temporarily to bypass hanging corpse smoke crash. Crash after logos with proton experimental 20221012
While my hardware was lacking, I experienced no bugs which weren't already synonymous with the game.
Works fine out of the box. With contoller there is no way to skip the logo but works fine afterwards.
Was able to get into a controller locked state where I had to use mouse emulation to exit the in game pc
The game crash bug is annoying but can be avoided by switching Proton versions temporarily. Other than that, game runs fine.
PROTON_NO_ESYNC=1 %command%
Used older GE-Proton 7.16 to avoid a game crash bug when interacting with the hanging corpse, but using this version causes graphical video/menu artifacts. Still, you can use this version to progress further in the game, and then you can probably switch back to a more recent version not having the video/menu artifacts.
Very slight performance hiccups, but probably the game's fault, not Proton/Wine/etc.
Sometimes, game won't start (black screen). But this happens infrequently. PROTON_NO_ESYNC=1 maybe helps, but in my case it probably doesn't. Just try again if it happens.
Using a recent version of Proton, Proton Experimental or GE-Proton, the game crashes shortly after interacting with the hanging corpse. So far this crash has been consistent. Using the older GE-Proton 7.16 helped with this, but caused another (smaller) issue with graphical artifacts in videos. Recommendation: use recent proton by default, but temporarily switch to 7.16 or so when you encounter the crash bug. I didn't try other versions, just these.

Proton Experiemental and GE-Pronton7-29 freezes the loadingscreen of the actual game. GE-Proton7-28 runs beautifully without any tinkering.
Use GE-Proton7-28
PROTON_NO_ESYNC=1 %command%
I don't know what version "Proton-GE" is in Steam, however I had to manually set my proton version to "Proton-7.2-GE-2" to play this game. I did not try playing with default proton settings, generally Proton GE works better than default. The issue I was having was that when you see the hanging corpse (trying to avoid spoilers) the game would crash on interaction. If you have a similar issue, or know what I'm talking about, try changing your Proton version.

The game itself is kind of buggy and often forgets settings, but it's just one developer, cut them some slack. :)
PROTON_NO_ESYNC=1 %command%
Game crashes at the loading screen sometimes; disabling ESYNC seems to help with this.
This is a really good indie game, it's a little buggy and has some stuttering in-game, but it's worth the trouble.
Works great
I had therefore to disable VSync to be able to continue a shift since last update
Just works great
I had a display/lightning bug on an ending but I'm not sure it is related to proton
Game seems to run fine as is. Base controller layout works well and the game is decently stable. Other than the constant stuttering that is.
Tweaked some in-game settings as well as setting the refresh rate to 40hz.
Game stutters on medium settings. Stays above 30fps though.
Other than the stutter it plays well. And gets about 3 hours of playtime. Will probably switch to pc for this personally though.

I open the game, it shows the unity logo but as it loads it crashes
The logo of the game appears with a red exclamation mark at the top left of the logo, I have no idea what it is.