I have tried multiple Proton versions, multiple mice, Wayland, Xorg, CPU troubleshooting and was still unsuccessful. The frame times would go up after an hour of gametime while moving the cursor/camera. The cursor and the ground spells would disappear on some World Bosses and make the game that much harder. This might all be hardware or configuration specific so your mileage may vary. I currently use Heroic Games Launcher with Wine GE. Gemstore did not work for me on defaul Wine, but does on Glorious Eggroll version.