The native version is completely borked - audio didn't play at all and whenever I could finally get a game to start (which was not often, given the play button had a habit of popping in and out of existence), it froze immediately.

I gave up and tried the Proton version, which did not run at all on the latest Proton, nor the latest Proton-GE. Following other reviews, here I eventually tried Proton 3.7, which works flawlessly.