Garuda Linux is Arch based for those of you who may not know of it.

I used Proton Experimental (but don't know that that was required). There was a red screen upon loading but like another user suggested, I just alt tabbed to the game and it all worked fine.

I also tested I was able to go to magic town, bought a wand, travelled back home, saved...and when I quit then reloaded the game my save was fine. (Tested this as I had seen someone on reddit say they weren't able to save after travelling -- note there was no save button while in magic town, but I think that may be normal.)