As mentioned; must launch in fullscreen + ditch opening cinematic, after that, playing in single-player works fine. No success was had trying to emulate a virtual desktop to circumvent the fullscreen requirement, although I still believe it to be possible. (I tried using https://wiki.winehq.org/FAQ#How_do_I_get_Wine_to_launch_an_application_in_a_virtual_desktop.3F this argument in the launch options to various bad affects, then tried winecfg in the prefix, but it seemed to do nothing.)