If playing out of the box: In Steam Input, bind "," and "." to left/right on left joystick, bind arrowkeyup and arrowkeydown to up/down on left joystick, bind "a" (keyboard) to the A button, and bind "Space" to X. On right trackpad/joystick, lower vertical scaling to 0. Bind Enter to a convenient key for navigating menus. These cover the most basic controls; jumping, running, and aiming.

By default, full mouselook is disabled and can't be enabled without editing ini files (or installing third-party patches). If you opt to play like this, you'll be at the mercy of Blood's generous auto-aim, and can't take advantage of vertical aim for arcing dynamite throws.

As mentioned above, Blood doesn't have full mouseaim support out of the box. Even if you do enable mouseaim through ini tinkering, the implementation is very poor. Blood can only update one mouse axis at a time, resulting in stiff, jittery aiming.

Blood was never very performant on DOS, and it's even less so on DOSbox/Proton. Expect your framerate to fluctuate and hitch significantly if playing out of the box.