Dialog related to items crafted in the lower left corner gets pretty blurry but if you are early game (like me) you can make pretty educated guesses as to what each line says because you're doing a lot of hand crafting. Dialogue from NPCs can be somewhat easier to read but are being written on the lower edge of the bubble so as to meld with the bottom boundary.

In early game you have to crank start your drills with a cute little mini-game, for me the mouse works everywhere just fine but. In that cranking mini-game, sometimes I just cannot get the handle to move properly. Only restarting the software seems to temporarily fix this behavior. Everywhere else, outside of this aspect, all controls respond exactly as you'd expect. I've tried changing a couple dozen different aspects of mouse emulation including (but certainly not only) setting up the left trackpad as another mouse input and even the right joystick. Each separate element has produced the same glitchy behavior.