

gamemoderun %command
Occasional matchmaking issues, but most players seem to experience this

Works again, despite easyanticheat
After numerous reinstalls, the game started working again. I have it working with both proton 6.3-8 and the current proton experimental
Runs like native. EAC has recently been added but does not seem to cause any issues with Proton.
Occasional connection issues, but these seem to be shared by all users.
Using anything newer than Proton 6.3.8 seems to cause significant stability issues including frequent crashes. Have not tried the latest Experimental though. EAC does not seem to have borked the game as of now.

EasyAntiCheat
They added EasyAntiCheat in an update today. Currently it no longer boots on any version of proton, despite the EasyAntiCheat runtime being installed.
Works very well out of the box.
Occasional connectivity issues but players on Windows seem to experience them as well.
Worked perfectly out of the box and didn't have to do anything to get it working, just pressed play and it worked.
No issues at all. It plays like native.
Your mileage may vary if you're using something other than pulseaudio, but worth a shot as it's a great game
Only change I have made is using a GE version of Proton (https://github.com/GloriousEggroll/proton-ge-custom/releases) I used version 6.5-GE-2, no other tinkering or launch options. Previous report mentions VOIP not working for him/her but it worked just fine for me.
If your VOIP is not working (default keybind is left Ctrl) you can use the in-game VOIP fix - Press ESC and look for "Having VOIP Problems?" (top left) and follow those instructions.
I had VoIP issues; please do provide solutions if you find any
Most features worked, but my VoIP input didn't seem to work because other players wouldn't respond when I used the VoIP feature. I could hear their voices just fine though. Voice chat is a crucial part of this game, so my gameplay was very limited.