The cursor traveled really slowly from side to side whether I had settings to lowest or where I ran the game with default graphics settings

at "Orpheus's Dream Configuration" --> Even at resolution 720 x 400, graphics on Medium fullscreen(not Windowed) the game is slow

Significant performance issues may be caused by my graphics card being low-end or game's graphics engine keeping all rooms in active memory as more rooms are explored. You can make a setting for visuals which I had set to lowest.