Game works out of the box without any issues ( Arch Linux here ). I selected Proton Experimental, and the game ran smoothly right from the start.

I read that some users had to change a line in the configuration 'poe2_production_Config.ini' within the game directory to get it working with NVIDIA graphics cards. However, that wasn't the case for me, as I’m using an RTX 3070 TI, and everything worked perfectly. Overall, I’m very satisfied with the performance and stability of the game on Linux. I highly recommend.