For my system with Proton-5.21-GE-1:

1. Out of the box solution, e.g. without any launch options works perfectly
2. While adding >> PROTON_NO_ESYNC=1 PROTON_NO_D3D11=1 PROTON_USE_WINED3D11=1 %command% << to launch options makes the game playable ( i was able to run & play it), but with a lot of animation speed/loading problems, feeling like entire game is stalling.