There didn't seem to be any audio that played during the splashscreen. But since I haven't loaded this up on windows in a really long time. I don't know if that's how it has always been. Otherise, the audio seemed fine during the first two levels I tried.

I only played the first two levels, and watched the intro all the way through. Every thing seemed fine. No major frame drops or anything. I almost always had a stable 75 frames. And every once in a while it went down or up by 1, so nothing serious.

TL:DR; No tweaks seem to be necessary. I simply installed the game and it loaded up fine.