Many Resident Evil games are made on the old MT Framework engine, and therefore they have the same problems - terrible stutters when running on Linux via DXVK. The worst is Resident Evil 6, where stutters in cutscenes are simply incredibly annoying and break the game. And it doesn't matter which Proton you use - there are problems everywhere. But in the case of GE Proton, at least you don't have to install wmp11 codecs manually, because in GE Proton, the video in the game works by default. Nevertheless, there are terrible stutters everywhere. But there is still a solution.

You need to force the game to launch using (outdated) OpenGL instead of DXVK. That is, you need to do the following: 1) use GE Proton 2) specify the launch parameter: "PROTON_USE_WINED3D %command%" - this way the game will launch using regular Wine's OpenGL instead of DXVK. If you use SteamTinkerLaunch, you can enable the same option by checking the box next to "Proton use WINED3D" in the "GAME MENU" in STL (I also recommend checking the boxes next to "Dxvk async" and "Game mode"). In my case, using OpenGL in games on this engine helped to get rid of ~ 90% of stutters and glitches in the game. It's a shame I discovered this option so late.